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The activity of sat...
The activity of satellite cells and myonuclei following 8 weeks of strength training in young men with suppressed testosterone levels
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- Kvorning, T (author)
- Team Danmark, The House of Sport, Brøndby, Denmark; Institute of Sport Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark,RISPA/ MEP-RG
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- Kadi, Fawzi, 1970- (author)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,RISPA- MEP-RG
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- Schjerling, P (author)
- Institute of Sports Medicine, Department of Orthopedic Surgery, Bispebjerg Hospital, Copenhagen, Denmark; Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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- Andersen, M (author)
- Department of Endocrinology, Odense University Hospital, Odense, Denmark
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- Brixen, K (author)
- Department of Endocrinology, Odense University Hospital, Odense, Denmark
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- Suetta, C (author)
- Division of Clinical Physiology and Nuclear Medicine, Department of Diagnostics, Glostrup University Hospital, Copenhagen, Denmark
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- Madsen, Klavs, 1957 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kost- och idrottsvetenskap,Department of Food and Nutrition, and Sport Science
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(creator_code:org_t)
- 2014-11-15
- 2015
- English.
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In: Acta Physiologica. - : Wiley. - 1748-1708 .- 1748-1716 .- 0001-6772. ; 213:3, s. 676-687
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- AIM: To investigate how suppression of endogenous testosterone during an 8-week strength training period influences the activity of satellite cells and myonuclei.METHODS: Twenty-two moderately trained young men participated in this randomized, placebo-controlled, and double-blinded intervention study. The participants were randomized to treatment with a GnRH analogue, goserelin (n = 12), which suppresses testosterone or placebo (n = 10) for 12 weeks. The strength training period of 8 weeks started after 4 weeks of treatment and included exercises for all major muscles. Biopsies were obtained from the mid-portion of the vastus lateralis muscle.RESULTS: Testosterone resting level in goserelin was 10-20 times lower compared with placebo, and the training-induced increase in the level of testosterone was abolished in goserelin. Training increased satellite cells number in type II fibres by 20% in placebo and by 52% in goserelin (P < 0.01), whereas the myonuclear number significantly increased by 12% in type II fibres in placebo and remained unchanged in goserelin (P < 0.05). No changes in satellite cells and myonuclei were seen in type I fibres in either group. Data from the microarray analysis indicated that low testosterone affects the bone morphogenetic proteins signalling, which might regulate proliferation vs. differentiation of satellite cells.CONCLUSION: Eight weeks of strength training enhances the myonuclear number in type II fibres, and this is largely blocked by the suppression of testosterone. The data indicate that low testosterone levels could reduce the differentiation of satellite cells to myonuclei via the bone morphogenetic proteins signalling pathway, resulting in reduced increases in lean leg mass.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Idrottsvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Sport and Fitness Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Keyword
- GnRH analogue; Microarray; Myonuclei; Satellite cells; Testosterone; Training
- Sports Science
- Idrottsvetenskap
- Fysiologi
- Physiology
- GnRH analogue;microarray;myonuclei;satellite cells;testosterone;training
Publication and Content Type
- ref (subject category)
- art (subject category)
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